Custom Peptides
Cayman Chemical MCC950sodIum salt 10mg
An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg
Cayman Chemical HIstatIn 8trIfluoroacetAT 10mg
An antimicrobial peptide; active against colistin-sensitive and -resistant strains of A. baumannii at 32 UG/ml; active against C. albicans and C. tropicalis (MICs = 1 and 5 mg/ml, respectively)
Cayman Chemical LysIpresInacetate 10mg
A peptide hormone; an agonist of V1A receptors; binds to rat and human V1A receptors (Kis = 1.2 and 10.1 nM, respectively); increases intracellular calcium levels in cultured rat and human aortic cells (Kact = 12 and 20.8 nM, respectively); induces vasoconstriction in isolated mesenteric arteries from normotensive and spontaneously hypertensive rats; has antidiuretic effects in non-anesthetized dwarf pigs
Cayman Chemical ImethrIdInhydrobromIde 10mg
A potent histamine H3 receptor agonist (Ki = 0.85 nM); selective for histamine H3 over histamine H4 receptors (Ki = 245 nM); inhibits cAMP-stimulated β-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM); induces a decrease of the electrically induced twitch contraction in isolated guinea pig ileum; inhibits hydrochloric acid-induced formation of gastric lesions in rats at 30 mg/kg, s.c.
Cayman Chemical Rosamultn 10mg
A triterpenoid glycoside with diverse biological activities; inhibits HIV-1 protease by 52.9% in a cell-free assay at 100 µM; reduces hydrogen peroxide-induced apoptosis, increases in MDA levels, and decreases in Sod, Cat, and Gpx activities in H9c2 rat cardiomyocytes at 0.01 nM; increases survival, prevents decreases in body weight, and protects against splenic and intestinal damage in irradiated mice at 12 mg/kg; inhibits acetic acid-induced writhing in mice at 30 mg/kg, p.o.
Cayman Chemical 5-FeruloylquInIc AcId 10mg
A chlorogenic acid with antioxidant activity; scavenges DPPH and superoxide anion radicals in cell-free assays (IC50s = ~9 and ~36 µM, respectively)
Cayman Chemical AL 34662formate 10mg
A 5-HT2 receptor agonist; selectively binds to 5-HT2 receptors (IC50 = 1.5 and 0.77 nM in isolated and washed human or rat cerebral cortex homogenates, respectively) over a panel of 19 neurotransmitter and steroid receptors at 10 µM; induces calcium mobilization in a reporter assay using primary human ciliary muscle cells (EC50 = 140 nM); reduces IOP in a cynomolgus monkey model of trabeculoplasty-induced ocular hypertension at 100 or 300 UG/eye
Cayman Chemical 4-oxo IsotretInoIn 10mg
An active metabolite of isotretinoin; increases protein expression of CK7 and CK19 in normal human epidermal keratinocytes at 10 µM; inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 HNSCC cells; has been found in influent and effluent wastewater; is teratogenic to embryos when administered to pregnant dams at 100 mg/kg on day 11 of gestation
Cayman Chemical 2propyl4PentenoIc AcId 10mg
A metabolite of valproic acid; undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats; neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos
Cayman Chemical SAVOLITINIB 10MG
An inhibitor of c-Met (IC50 = 5 nM); selectivity inhibits c-Met over 274 other kinases at 1 µM; inhibits c-Met autophosphorylation in NCI H441 human NSCLC cells (IC50 = 3 nM); inhibits HGF-induced growth of NCI H441 cells (IC50 = 6 nM); inhibits proliferation in a panel of gastric cancer cells with dysregulated c-Met (EC50s = 0.6-14.7 nM); inhibits intratumor c-Met autophosphorylation by 94% and reduces tumor growth in a Hs 746T human stomach cancer mouse xenograft model at 3 mg/kg
Cayman Chemical TIagabInhydrochlorIde 10mg
A GAT-1 inhibitor (IC50 = 49 nM); inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.); reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg; acts synergistically with gabapentin to delay pain responses in mice in the hot plate test
Cayman Chemical ChebulInIc AcId 10mg
An ellagitannin with diverse biological activities; an inhibitor of PTPN9 and PTPN11 (IC50s = 34 and 37 nM, respectively); increases glucose uptake in 3T3-L1 preadipocytes at 5 µM; induces apoptosis of HL-60 and NB4 APL, but not K562 CML, cells (IC50s = 7.5, 5, and >60 µM, respectively); reduces glycer-AGE-induced ROS production in HUVECs at 25 µM; reduces glutamate-induced ROS production and cell death in HT22 mouse hippocampal cells; inhibits H+/K+-ATPase activity (IC50 = 65.01 UG/ml)
Cayman Chemical 1MethylhIstamInhydrochLR 10mg
A major metabolite of histamine used as a biomarker of histaminergic system activity via CSF levels in Alzheimer’s disease patients
Cayman Chemical Cholesta-3 5-dIen-7-on 10mg
An oxysterol and a negative allosteric modulator of GABAA receptors; reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors (IC50s = 1.5 and 1 µM, respectively); reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse DRG neurons; increases latency to nocifensive behaviors in the hot plate test in mice at 2, 10, and 50 mg/kg
Cayman Chemical ZIprasIdonhydrochLRIde hy 10mg
An atypical antipsychotic; an agonist of 5-HT1A receptors (EC50 = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT1D receptors (IC50 = 2.69 nM) and a partial agonist of 5-HT1B receptors (EC50 = 6.17 nM) in [35S]GTPγS binding assays; an antagonist at 5-HT2A and dopamine D2 receptors (Kis = 1.15 and 1.29 nM, respectively) in cell-based assays; inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID50s = 1.53 and 2.43 mg/kg, respectively)